Amsterdam-Zuidoost is a borough (stadsdeel) of Amsterdam, Netherlands. It consists of four residential neighborhoods—Bijlmermeer, Venserpolder, Gaasperdam and Driemond—as well as the Amstel III/Bullewijk Business Park and the Amsterdam Arena entertainment and shopping district.

Geographically, Amsterdam-Zuidoost is an exclave of Amsterdam as it does not border any of the other boroughs. As of 2013, Amsterdam-Zuidoost had almost 84,000 inhabitants.